Description

5-[[3-Bromo-4-(2-Cyclohexylethoxy)Phenyl]Methylene]-2,4-Thiazolidinedione-D4 is a high-purity, deuterium-labeled analog of a thiazolidinedione derivative, serving as a critical internal standard and reference material in advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolite Tracing & Pharmacokinetics (PK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Method Development & Validation: Critical for developing and validating robust, sensitive, and specific bioanalytical methods in compliance with FDA, EMA, and ICH guidelines.
• Drug Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradation products during pharmaceutical manufacturing.
• Metabolomics Research: Facilitates high-throughput screening and discovery in studies investigating metabolic pathways and disease mechanisms.
• Quality Control & Assurance: Supports in-house QC laboratories in maintaining stringent quality standards for active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	5-[[3-Bromo-4-(2-Cyclohexylethoxy)Phenyl]Methylene]-2,4-Thiazolidinedione-D4
CAS No.	1795135-31-7
Molecular Formula	C18H19D4BrNO3S
Molecular Weight	Contact for details
Synonyms	5-[(3-Bromo-4-[(2-cyclohexylethoxy)phenyl])methylene]-2,4-thiazolidinedione-d4; 5-[[3-Bromo-4-(2-Cyclohexylethoxy)Phenyl]Methylene]thiazolidine-2,4-dione-d4; Deuterated TZD Derivative; [3-Bromo-4-(2-cyclohexylethoxy)benzylidene]thiazolidine-2,4-dione-d4; Thiazolidinedione-d4 derivative; Bromo-cyclohexylethoxy-benzylidene-thiazolidinedione-d4; Stable Isotope Labeled Thiazolidinedione; Internal Standard for PPARγ Ligand Analysis
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, meeting the exacting standards of analytical research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity (HPLC), and identity confirmation (NMR, MS). We adhere to relevant ICH Q2(R1) guidelines for analytical procedure validation to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.