Description

2-[(E)-1-(4-Methylphenyl)-3-(2,2,3,3,4,4,5,5-Octadeuteriopyrrolidin-1-Yl)Prop-1-Enyl]Pyridine:Hydrochloride is a high-purity, deuterated chemical compound designed for advanced research and development applications. This material is particularly valuable as a stable isotope-labeled internal standard or tracer in analytical chemistry, enabling precise quantification and metabolic pathway studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery, pharmacokinetics, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering reference compound in quantitative bioanalysis for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: Used in stable isotope labeling experiments to track the fate of molecules in biological systems, providing insights into drug metabolism.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products during drug substance development.
• Proteomics and Biomarker Research: Can be employed in chemical proteomics or as a component in synthesizing labeled probes for target engagement studies.
• Reference Material for Method Validation: Provides a certified standard for validating analytical methods in compliance with ICH, FDA, and EMA guidelines.
• Synthetic Intermediate: Acts as a deuterated building block for the synthesis of more complex labeled compounds in medicinal chemistry.

Basic Information

Product Name	2-[(E)-1-(4-Methylphenyl)-3-(2,2,3,3,4,4,5,5-Octadeuteriopyrrolidin-1-Yl)Prop-1-Enyl]Pyridine:Hydrochloride
CAS No.	1795134-06-3
Molecular Formula	C20H17D8N2·HCl
Molecular Weight	~344.94 g/mol
Synonyms	2-[(E)-1-(p-Tolyl)-3-(2,2,3,3,4,4,5,5-octadeuteriopyrrolidin-1-yl)prop-1-en-1-yl]pyridine hydrochloride; Deuterated Pyrrolidine Derivative Hydrochloride; (E)-2-[1-(4-Methylphenyl)-3-(octadeuteriopyrrolidin-1-yl)prop-1-en-1-yl]pyridine hydrochloride; 1795134-06-3; Labeled Internal Standard 1795134-06-3; d8-Pyrrolidine Derivative HCl Salt; Deuterated Analog Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ²H), HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing assay purity, isotopic enrichment (D-atom %), and impurity profiles. We support compliance with relevant regulatory frameworks for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.