Description

1-(4-Methoxyphenyl)-n-(Trideuteriomethyl)Propan-2-Amine:Hydrochloride is a deuterated derivative of a substituted phenethylamine, specifically designed for research and development applications where isotopic labeling is critical. This compound is valued for its role as a stable isotope-labeled internal standard or tracer in analytical chemistry, enabling precise quantification and metabolic studies. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract development and manufacturing organizations (CDMOs) focused on advanced drug discovery and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterium-labeled internal standard in Liquid Chromatography-Mass Spectrometry for the accurate quantification of its non-deuterated counterpart in complex biological matrices.
• Metabolic Pathway Tracing: Used in pharmacokinetic and drug metabolism studies to trace and elucidate metabolic pathways and identify metabolites.
• Reference Material for Analytical Methods: Acts as a high-purity certified reference material (CRM) for the validation and calibration of analytical methods in compliance with GLP and GMP guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in IDMS techniques to achieve high accuracy and precision in quantitative analysis, minimizing matrix effects.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug substance development.
• Neurochemical Research: Investigated in preclinical research for its potential interactions with neurotransmitter systems, leveraging the deuterium isotope effect.

Basic Information

Product Name	1-(4-Methoxyphenyl)-n-(Trideuteriomethyl)Propan-2-Amine:Hydrochloride
CAS No.	1795033-58-7
Molecular Formula	C11H16D3ClNO
Molecular Weight	215.75 g/mol (for monoisotopic mass)
Synonyms	4-Methoxy-N-(trideuteriomethyl)amphetamine hydrochloride; 1-(4-Methoxyphenyl)-N-(trideuteriomethyl)propan-2-amine hydrochloride; 4-Methoxy-N-(CD3)-amphetamine HCl; p-Methoxy-N-(trideuteriomethyl)phenethylamine hydrochloride; 4-Methoxy-N-methyl-d3-amphetamine hydrochloride; 1-(4-Methoxyphenyl)-2-((trideuteriomethyl)amino)propane hydrochloride; PMMA-d3 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Methoxyphenyl)-n-(Trideuteriomethyl)Propan-2-Amine:Hydrochloride is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for isotopic purity and chemical identity. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay, isotopic enrichment, and impurity profile as determined by advanced spectroscopic and chromatographic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.