Description

4-[4-(4-Chlorophenyl-D4)-4-Hydroxy-1-Piperidinyl]-1-(2-Fluorophenyl)-1-Butanone is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled analog, which is critical for conducting precise metabolism, pharmacokinetic (PK), and bioanalytical studies. This compound is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and receptor-targeted drug classes.

Application

• Deuterated Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for accurate bioanalysis.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to trace and quantify the parent drug and its metabolites in biological matrices without interference from endogenous compounds.
• Pharmaceutical Impurity Profiling: Acts as a marker or reference compound for identifying and quantifying process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Preclinical and Clinical Research: Essential for ensuring data accuracy and regulatory compliance in studies required for Investigational New Drug (IND) and New Drug Application (NDA) submissions.
• Synthesis of Labeled Drug Candidates: Used as a building block in the synthesis of more complex deuterated drug molecules for enhanced metabolic stability.
• Forensic and Anti-Doping Analysis: Can be employed as a high-specificity reference material in forensic toxicology and sports drug testing.

Basic Information

Product Name	4-[4-(4-Chlorophenyl-D4)-4-Hydroxy-1-Piperidinyl]-1-(2-Fluorophenyl)-1-Butanone
CAS No.	1795021-11-2
Molecular Formula	C21H18D4ClFNO2
Molecular Weight	377.88 g/mol
Synonyms	1-(2-Fluorophenyl)-4-[4-hydroxy-4-(4-chlorophenyl-d4)-1-piperidinyl]-1-butanone; 4-[4-(4-Chlorophenyl-2,3,5,6-d4)-4-hydroxy-1-piperidinyl]-1-(2-fluorophenyl)-1-butanone; 4-(4-(4-Chlorophenyl-d4)-4-hydroxypiperidin-1-yl)-1-(2-fluorophenyl)butan-1-one; Deuterated Haloperidol Metabolite II Analog; Haloperidol-d4 Metabolite (Reduced Ketone); 4-(4-Hydroxy-4-(4-chlorophenyl-d4)piperidino)-1-(2-fluorophenyl)-1-butanone
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analytical characterization using NMR (1H, 13C), HPLC, and Mass Spectrometry to confirm chemical structure, isotopic enrichment (D-content), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided and traceable to relevant standards for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere (e.g., argon or nitrogen) to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.