Description

2,3,5,6-Tetradeuterio-4-(1,1-Dioxothiazinan-2-Yl)Benzenesulfonamide is a deuterated derivative of a benzenesulfonamide compound, serving as a critical stable isotope-labeled standard. This high-purity compound is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly mass spectrometry. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers for use as an internal standard in pharmacokinetic, metabolomic, and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the precise quantification of its non-deuterated counterpart or related metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical in DMPK studies to track drug absorption, distribution, metabolism, and excretion with high fidelity, minimizing matrix effects.
• Biomarker Analysis: Enables accurate measurement of specific biomarkers in complex samples for clinical research and diagnostic assay development.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradation products during drug development and quality control.
• Metabolomics Research: Facilitates precise comparative analysis in metabolomic studies to understand disease mechanisms and therapeutic responses.
• Regulatory Submissions: Supports bioanalytical method validation data packages required for regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	2,3,5,6-Tetradeuterio-4-(1,1-Dioxothiazinan-2-Yl)Benzenesulfonamide
CAS No.	1795021-05-4
Molecular Formula	C10H9D4N2O4S2
Molecular Weight	301.38 g/mol (for deuterated form)
Synonyms	4-(1,1-Dioxo-1,2-thiazinan-2-yl)-2,3,5,6-tetradeuteriobenzenesulfonamide; Deuterated Sulfonamide Internal Standard; [2H4]-4-(1,1-Dioxothiazinan-2-yl)benzenesulfonamide; 2,3,5,6-Tetradeutero-4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide; Benzenesulfonamide, 2,3,5,6-tetradeuterio-4-(1,1-dioxo-1,2-thiazinan-2-yl)-; Isotope Labeled Sulfonamide; D4-4-(1,1-Dioxothiazinan-2-yl)benzenesulfonamide
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, isotopic enrichment, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (LC-MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.