Description

Sodium α-Oxoisocaproate-D7 is a high-purity, deuterium-labeled derivative of α-ketoisocaproic acid, a key intermediate in leucine metabolism. This stable isotope-labeled compound is essential for advanced research requiring precise metabolic tracing and quantification. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic researchers in the fields of metabolomics, stable isotope-resolved metabolomics (SIRM), and drug development studies.

Application

• As an internal standard for the accurate quantification of α-ketoisocaproic acid and related metabolites in biological samples via LC-MS or GC-MS.
• For metabolic flux analysis and tracer studies to investigate branched-chain amino acid (BCAA) metabolism and its dysregulation in diseases.
• In pharmaceutical research for studying drug effects on metabolic pathways involving leucine catabolism.
• Use in clinical research for developing diagnostic assays related to metabolic disorders like maple syrup urine disease (MSUD).
• As a critical reagent in the synthesis of deuterium-labeled versions of more complex biomolecules for research.
• For NMR spectroscopy studies, leveraging the deuterium labels to simplify spectra and track molecular fate.

Basic Information

Product Name	Sodium α-Oxoisocaproate-D7
CAS No.	1795020-84-6
Molecular Formula	C6H2D7NaO3
Molecular Weight	~163.16 g/mol (for unlabeled sodium salt)
Synonyms	Sodium 4-Methyl-2-oxopentanoate-D7; Sodium α-Ketoisocaproate-D7; Sodium 2-Oxo-4-methylvalerate-D7; 4-Methyl-2-oxopentanoic-3,3,4,4,5,5,5-d7 acid sodium salt; KIC-D7 sodium salt; α-KIC-D7 sodium salt; 2-Ketoisocaproic acid-D7 sodium salt; 2-Oxoisocaproate-D7 sodium salt
EINECS	Contact for details

Quality Control

Every batch of Sodium α-Oxoisocaproate-D7 is manufactured and tested under strict quality management systems. We ensure high chemical purity and isotopic enrichment to meet the exacting standards of analytical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity (HPLC/NMR), isotopic purity (D-enrichment %), and identity confirmation is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain purity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.