Description

3-[1-[4,4-Bis(4-Fluorophenyl)Butyl]-3,3,4,5,5-Pentadeuteriopiperidin-4-Yl]-1H-Benzimidazol-2-One is a deuterated benzimidazolone derivative of significant interest in advanced pharmaceutical research and development. This compound is specifically engineered to serve as a stable isotope-labeled internal standard, a critical tool for ensuring the accuracy and reliability of quantitative bioanalytical methods. It is primarily utilized by research scientists and analytical chemists in pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on metabolism, pharmacokinetics, and drug safety studies.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track drug absorption, distribution, metabolism, and excretion (ADME) with high specificity.
• Bioanalytical Method Development and Validation: A key component in establishing robust, regulatory-compliant analytical assays for preclinical and clinical trials.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry.
• Pharmaceutical Impurity Testing: Can be employed as a reference standard to identify and quantify process-related impurities or degradants.
• Toxicology and Safety Assessment: Supports accurate exposure assessments in safety studies required for regulatory submissions.

Basic Information

Product Name	3-[1-[4,4-Bis(4-Fluorophenyl)Butyl]-3,3,4,5,5-Pentadeuteriopiperidin-4-Yl]-1H-Benzimidazol-2-One
CAS No.	1794979-08-0
Molecular Formula	C28H25D5F2N3O
Molecular Weight	Contact for details
Synonyms	3-[1-[4,4-Bis(4-Fluorophenyl)Butyl]-3,3,4,5,5-Pentadeuteriopiperidin-4-Yl]-1H-Benzimidazol-2-One; Deuterated Benzimidazolone Derivative; [D5]-Labeled Internal Standard; 3-[1-[4,4-Bis(4-Fluorophenyl)Butyl]piperidin-4-yl]-1H-benzimidazol-2-one-d5; Pentadeuterio Analog; Stable Isotope-Labeled Standard; LC-MS Internal Standard; Pharmacokinetic Research Standard.
EINECS	Contact for details

Quality Control

Every batch of this deuterated standard is produced and analyzed under strict quality protocols to ensure exceptional isotopic purity and chemical identity, which are paramount for its function. Our quality control includes advanced spectroscopic and chromatographic techniques to verify structure and purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data including assay, isotopic enrichment, and impurity profile, supporting compliance with GLP and ICH guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive). Store under an inert atmosphere if the container is opened repeatedly. Keep the container in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.