Description

n-Methyl-3-(1-Methyl-4-Piperidinyl)-1-(Phenylmethyl)-1H-Indole-5-Ethanesulfonamide-D3 is a deuterated isotopologue of a key pharmaceutical intermediate, offering enhanced metabolic stability for advanced research and development. This compound is critical for drug discovery programs, particularly in the development of deuterated drug candidates where improved pharmacokinetic profiles are desired. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers focused on innovative therapeutic agents.

Application

• Deuterated Drug Candidate Synthesis: Serves as a crucial building block for creating deuterium-labeled pharmaceuticals with potential for improved metabolic stability and extended half-life.
• Metabolic Pathway Studies: Used as a stable isotope-labeled internal standard in LC-MS/MS for accurate quantification and metabolism studies of its non-deuterated counterpart.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Research: Enables tracing and detailed analysis of drug absorption, distribution, metabolism, and excretion in preclinical models.
• Reference Standard for Analytical Methods: Provides a high-purity standard for the development and validation of analytical methods in quality control laboratories.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by allowing scientists to probe the effect of deuterium substitution on biological activity.
• Isotope Effect Investigation: Used in fundamental research to study kinetic isotope effects (KIE) in biochemical and chemical reactions.

Basic Information

Product Name	n-Methyl-3-(1-Methyl-4-Piperidinyl)-1-(Phenylmethyl)-1H-Indole-5-Ethanesulfonamide-D3
CAS No.	1794937-02-2
Molecular Formula	C25H30D3N3O2S
Molecular Weight	~ 440.62 g/mol (deuterated form)
Synonyms	1H-Indole-5-ethanesulfonamide, N-methyl-3-(1-methyl-4-piperidinyl)-1-(phenylmethyl)-, D3-labeled; Deuterated Alosetron Impurity/Intermediate; 1-(Benzyl)-N-methyl-3-[(1-methyl-4-piperidinyl)]-1H-indole-5-ethanesulfonamide-d3; Alosetron-d3 related compound; Lotronex-d3 intermediate; GR 68755C-d3; [D3]-Alosetron precursor; Deuterium-labeled 5-HT3 receptor antagonist intermediate.
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR (for deuterium incorporation), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profile is provided with every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere to ensure product stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.