Description

2-[3-[4-(3,4-Dichlorophenyl)-1-Piperazinyl]Propyl-D6]-1,2,4-Triazolo[4,3-A]Pyridin-3(2H)-One Hydrochloride is a high-purity, deuterated chemical reference standard of significant value in pharmaceutical research and development. This compound is essential for advanced analytical applications, particularly in quantitative mass spectrometry, where its isotopic labeling provides critical internal standards for accurate pharmacokinetic and metabolic studies. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables accurate measurement of drug concentration over time, supporting ADME (Absorption, Distribution, Metabolism, Excretion) profiling and regulatory submissions.
• Metabolite Identification and Profiling: Used in mass spectrometry to differentiate drug-derived metabolites from endogenous compounds, facilitating metabolic pathway elucidation.
• Bioanalytical Method Development and Validation: A key component in developing robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Drug Impurity Testing and Characterization: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredient (API) batches.
• Clinical Trial Support: Provides reliable data for patient sample analysis during various phases of clinical trials.

Basic Information

Product Name	2-[3-[4-(3,4-Dichlorophenyl)-1-Piperazinyl]Propyl-D6]-1,2,4-Triazolo[4,3-A]Pyridin-3(2H)-One Hydrochloride
CAS No.	1794892-17-3
Molecular Formula	C19H18D6Cl2N6O • HCl
Molecular Weight	Contact for details
Synonyms	Deuterated Trazodone Metabolite mCPP-D6 Hydrochloride; 1-[3-(4-(3,4-Dichlorophenyl)piperazin-1-yl)propyl-d6]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride; 2-[3-[4-(3,4-Dichlorophenyl)-1-piperazinyl]propyl-1,1,2,2,3,3-d6]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride; m-Chlorophenylpiperazine-D6 (mCPP-D6) derivative; Deuterated Trazodone Impurity Standard; (3,4-Dichlorophenyl)piperazine-D6 triazolopyridine hydrochloride
EINECS	Contact for details

Quality Control

This deuterated standard is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and high-resolution mass spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (D6, atom % D), chemical purity, and confirming identity and structure. Our quality system is designed to meet the rigorous demands of GMP/GLP-compliant research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.