Description

6-[[3-[4-(2-Chlorophenyl)-1-Piperazinyl-D4]Propyl]Amino]-1,3-Dimethyl-2,4(1H,3H)-Pyrimidinedione is a high-purity, deuterated chemical building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a labeled analog, enabling critical studies in drug metabolism, pharmacokinetics (DMPK), and bioanalytical method development. This compound is essential for researchers and manufacturers in the pharmaceutical and contract research organization (CRO) sectors who require isotopically labeled standards for mass spectrometry and tracer studies.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a deuterium-labeled internal standard for the accurate quantification of its non-deuterated counterpart in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Employed in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates.
• Metabolite Identification and Profiling: Aids in the structural elucidation and tracking of drug metabolites using advanced spectroscopic techniques.
• Reference Standard for Quality Control: Serves as a certified reference material (CRM) for analytical method validation and quality assurance in API manufacturing.
• Biomedical Research: Utilized in preclinical research to study receptor-ligand interactions and biochemical pathways without interference from endogenous compounds.

Basic Information

Product Name	6-[[3-[4-(2-Chlorophenyl)-1-Piperazinyl-D4]Propyl]Amino]-1,3-Dimethyl-2,4(1H,3H)-Pyrimidinedione
CAS No.	1794883-40-1
Molecular Formula	C19H22D4ClN5O2
Molecular Weight	Contact for details
Synonyms	Deuterated Theophylline Derivative; 1,3-Dimethyl-6-[[3-[4-(2-chlorophenyl)-1-piperazinyl-D4]propyl]amino]-2,4(1H,3H)-pyrimidinedione; 6-((3-(4-(2-Chlorophenyl)piperazin-1-yl-D4)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione; Theophylline-D4 Piperazine Analog; 2-Chlorophenylpiperazine-D4 Theophylline Conjugate; Deuterated PDE Inhibitor Intermediate; Labeled Xanthine Derivative
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (for deuterium incorporation verification), HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and analytical data are provided with every shipment. We adhere to cGMP principles for manufacturing to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light). For long-term storage, consider keeping the container under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.