Description

1,1,1-Trideuterio-n-[(1-Ethylpyrrolidin-2-Yl)Methyl]Methanamine:Hydrochloride is a deuterated pyrrolidine derivative, a high-value specialty chemical designed for advanced research and development. This compound is critical for applications requiring isotopic labeling, offering enhanced metabolic stability and traceability in pharmacokinetic and mechanistic studies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on neuropharmacology and medicinal chemistry.

Application

• Isotopic Labeling in Pharmaceutical Research: Serves as a deuterium-labeled building block for the synthesis of novel drug candidates, enabling detailed ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Metabolite Identification & Tracing: Used in mass spectrometry-based assays to track metabolic pathways and identify drug metabolites with greater precision.
• Neurological & Psychiatric Drug Development: Acts as a key intermediate or reference standard in the development of compounds targeting neurotransmitter systems, given its pyrrolidine scaffold.
• Chemical Biology Probes: Employed in the creation of molecular probes to study enzyme function and receptor-ligand interactions in biological systems.
• Reference Standard for Quality Control: Provides an authenticated standard for the analytical validation and quality control of related active pharmaceutical ingredients (APIs) and impurities.

Basic Information

Product Name	1,1,1-Trideuterio-n-[(1-Ethylpyrrolidin-2-Yl)Methyl]Methanamine:Hydrochloride
CAS No.	1794827-45-4
Molecular Formula	C9H18D3N2•HCl
Molecular Weight	207.76 g/mol (approx.)
Synonyms	1,1,1-Trideuterio-N-[(1-ethyl-2-pyrrolidinyl)methyl]methanamine hydrochloride; Deuterated N-[(1-Ethylpyrrolidin-2-yl)methyl]methanamine hydrochloride; N-[(1-Ethyl-2-pyrrolidinyl)methyl]methanamine-d3 hydrochloride; 1,1,1-Trideuterio-N-[(1-ethylpyrrolidin-2-yl)methyl]methylamine hydrochloride; (1-Ethyl-2-pyrrolidinyl)methanamine-d3 hydrochloride; Deuterated Pyrrolidine Amine Hydrochloride; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and isotopic enrichment. Certificates of Analysis (COA) detailing specifications such as assay by HPLC, isotopic purity by NMR/MS, and related substance profiles are available upon request. We adhere to cGMP principles for the manufacture of reference standards and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.