Description

2-Ethoxy-1-[[2'-(4,5-Dihydro-5-Oxo-1,2,4-Oxadiazol-3-Yl)Biphenyl-4-Yl]Methyl]Benzimidazole-7-Carboxylic Acid-D4 is a high-purity, deuterated isotopologue of a key pharmaceutical intermediate. This compound is specifically designed for use in advanced analytical and research applications where isotopic labeling is critical, such as in the development of quantitative bioanalytical methods. It is an essential material for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those involved in drug metabolism and pharmacokinetics (DMPK) studies, method validation, and the synthesis of labeled reference standards.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering internal standard for the accurate quantification of its non-deuterated counterpart in complex biological matrices.
• Drug Metabolism Studies (DMPK): Used in tracer studies to investigate metabolic pathways, bioavailability, and excretion profiles of active pharmaceutical ingredients.
• Method Development and Validation: Essential for developing and validating robust, sensitive, and specific bioanalytical assays in compliance with regulatory guidelines (e.g., FDA, EMA).
• Synthesis of Deuterated Drug Candidates: Acts as a key building block in the research-scale synthesis of deuterated drug molecules for enhanced metabolic stability or as tracers.
• Quality Control and Reference Standard: Provides a certified reference material for in-house quality control laboratories to ensure the accuracy and precision of analytical results.

Basic Information

Product Name	2-Ethoxy-1-[[2'-(4,5-Dihydro-5-Oxo-1,2,4-Oxadiazol-3-Yl)Biphenyl-4-Yl]Methyl]Benzimidazole-7-Carboxylic Acid-D4
CAS No.	1794817-45-0
Molecular Formula	C26H19D4N4O5
Molecular Weight	Contact for details
Synonyms	2-Ethoxy-1-[[2'-(4,5-Dihydro-5-Oxo-1,2,4-Oxadiazol-3-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]-1H-Benzimidazole-7-Carboxylic Acid-d4; Deuterated Olmesartan Medoxomil Impurity/Intermediate; 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-, 4,5,6,7-tetradeuterio-; Olmesartan Medoxomil-d4; Olmesartan Impurity D-d4; [Tetradeuterio]-2-Ethoxy-1-[[2'-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic Acid
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems. Each batch of 2-Ethoxy-1-[[2'-(4,5-Dihydro-5-Oxo-1,2,4-Oxadiazol-3-Yl)Biphenyl-4-Yl]Methyl]Benzimidazole-7-Carboxylic Acid-D4 undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical and research use. Comprehensive Certificates of Analysis (COA) detailing HPLC purity, deuterium enrichment (D-content), and spectroscopic confirmation are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.