Description

1-(4-Chlorophenyl)Biguanide-D4 Hydrochloride is a deuterated analog of a biguanide derivative, serving as a critical stable isotope-labeled internal standard for analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based methods, particularly in pharmaceutical research and development. It is primarily utilized by analytical laboratories, CROs, and pharmaceutical companies engaged in method development, pharmacokinetic studies, and metabolite identification for related active pharmaceutical ingredients.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the precise quantification of 1-(4-Chlorophenyl)biguanide and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Supports method development and validation in drug discovery and development pipelines for compounds within the biguanide class.
• Metabolite Profiling: Aids in the identification and structural elucidation of drug metabolites during ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Clinical Research: Enables accurate therapeutic drug monitoring and pharmacokinetic/pharmacodynamic (PK/PD) modeling in clinical trial samples.
• Reference Standard: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity in GLP/GMP-compliant environments.

Basic Information

Product Name	1-(4-Chlorophenyl)Biguanide-D4 Hydrochloride
CAS No.	1794816-89-9
Molecular Formula	C8H5D4ClN5•HCl
Molecular Weight	263.15 g/mol (approx.)
Synonyms	1-(p-Chlorophenyl)biguanide-d4 hydrochloride; N-(4-Chlorophenyl)imidodicarbonimidic diamide-d4 hydrochloride; 4-Chlorophenylbiguanide-d4 HCl; Deuterated Chloroguanide impurity standard; Biguanide-d4 derivative; Stable Isotope Labeled Internal Standard (SIL-IS) for Chloroguanide; CPBG-d4 HCl
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Chlorophenyl)Biguanide-D4 Hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing parameters such as isotopic purity, chemical purity, and identity confirmation via advanced spectroscopic techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.