Description

o-Chlorohippuric Acid-D3 is a stable isotope-labeled analog of o-chlorohippuric acid, where three hydrogen atoms are replaced by deuterium. This compound is of significant value as an internal standard in quantitative analytical methods, particularly liquid chromatography-mass spectrometry (LC-MS), ensuring precise and accurate measurement of its non-labeled counterpart. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development, pharmacokinetic studies, and metabolomic research where high-fidelity quantification is critical.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the accurate quantification of o-chlorohippuric acid in complex biological matrices such as plasma, urine, and tissue homogenates.
• Metabolite Tracing and Pharmacokinetic Studies: Used in drug metabolism and disposition (DMPK) studies to track the fate of related compounds and calculate precise pharmacokinetic parameters.
• Biomarker Research and Validation: Supports the development and validation of robust analytical assays for potential biomarkers in clinical and preclinical settings.
• Quality Control in Reference Material Production: Serves as a critical component in preparing certified reference materials (CRMs) for laboratory proficiency testing and method calibration.
• Environmental and Food Safety Testing: Applicable in analytical methods designed to detect and quantify chlorinated aromatic compounds or their metabolites in environmental or food samples.

Basic Information

Product Name	o-Chlorohippuric Acid-D3
CAS No.	1794816-82-2
Molecular Formula	C9H5D3ClNO3
Molecular Weight	~216.63 g/mol
Synonyms	2-Chlorohippuric Acid-d3; (2-Chlorobenzoylamino)acetic-2,2,2-d3 Acid; N-(2-Chlorobenzoyl)glycine-d3; o-Chlorobenzoylglycine-d3; 2-Chlorobenzoylglycine-d3; Hippuric Acid, 2-chloro-, d3-labeled; Deuterated o-Chlorohippuric Acid; Internal Standard for o-Chlorohippuric Acid
EINECS	Contact for details

Quality Control

Every batch of o-Chlorohippuric Acid-D3 is produced and analyzed under strict quality management protocols to ensure high chemical purity and isotopic enrichment. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for identity, purity (HPLC), isotopic purity (NMR/MS), and specific tests for related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.