Description

2-Bromo-1,3-Bis(tert-Butyldimethylsilyloxy)Propane-D4 is a deuterated, silyl-protected synthetic intermediate of significant value in advanced organic synthesis. This compound matters for its role in introducing stable isotopic labels and protected functional groups into complex molecular architectures, enabling precise structural modifications and metabolic studies. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and deuterated APIs.

Application

• Deuterated API Synthesis: A key building block for incorporating deuterium atoms into active pharmaceutical ingredients (APIs) to potentially enhance metabolic stability, pharmacokinetics, and patent life.
• Isotope Labeling Reagent: Used in the preparation of isotopically labeled compounds for use as internal standards in mass spectrometry-based analytical methods (LC-MS, GC-MS).
• Protected Synthon for Medicinal Chemistry: Serves as a versatile, protected intermediate for constructing complex molecules in drug discovery and lead optimization campaigns.
• Agrochemical Intermediate: Employed in the research and development of novel, isotopically labeled agrochemicals and plant growth regulators.
• Organic Synthesis Research: Utilized in academic and industrial R&D for methodological studies involving carbon-deuterium bond formation and silyl ether chemistry.
• Precursor for Deuterated Polymers/Materials: Acts as a monomer or modifier for creating specialty polymers with deuterated segments for analytical or material science applications.

Basic Information

Product Name	2-Bromo-1,3-Bis(tert-Butyldimethylsilyloxy)Propane-D4
CAS No.	1794816-65-1
Molecular Formula	C₁₃H₂₅D₄BrO₂Si₂
Molecular Weight	369.52 g/mol (approx.)
Synonyms	1,3-Bis[(1,1-dimethylethyl)dimethylsilyl]oxy-2-bromopropane-1,1,3,3-d4; 2-Bromo-1,3-bis[(tert-butyldimethylsilyl)oxy]propane-d4; 2-Bromo-1,3-di-O-(tert-butyldimethylsilyl)-glycerol-d4; Deuterated 2-Bromo-1,3-bis(TBDMS-oxy)propane; 1,3-Bis-O-(TBDMS)-2-bromopropane-d4; TBDMS-protected deuterated bromopropanediol; 2-Bromo-1,3-bis(tert-butyldimethylsiloxy)propane-d4
EINECS	Contact for details

Quality Control

Our 2-Bromo-1,3-Bis(tert-Butyldimethylsilyloxy)Propane-D4 is manufactured under strict quality control protocols to ensure high isotopic and chemical purity for sensitive synthetic applications. Each batch is characterized by advanced analytical techniques including NMR (1H, 13C, 2H), HPLC, and GC-MS to confirm structure, isotopic enrichment, and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Area %)
Isotopic Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.