Description

4-Chloro-6-Methoxy-2-Methyl-n-(4,4,5,5-Tetradeuterio-1H-Imidazol-2-Yl)Pyrimidin-5-Amine is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable, isotopically labeled building block, enabling precise metabolic and pharmacokinetic studies for novel drug candidates. This compound is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on developing next-generation therapeutics, particularly in the areas of kinase inhibitors and targeted small-molecule drugs.

Application

• Deuterated Pharmaceutical Intermediate: Serves as a critical building block for synthesizing deuterium-labeled active pharmaceutical ingredients (APIs) to enhance metabolic stability and study drug metabolism.
• Metabolic Tracing & Pharmacokinetics (PK/PD): Used in the development of internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) to enable accurate quantification and detailed metabolic pathway analysis.
• Drug Discovery Research: Employed in medicinal chemistry programs for the synthesis and optimization of novel pyrimidine-based compounds targeting various disease pathways.
• Biochemical Probe Development: Acts as a precursor for creating labeled probes to investigate enzyme mechanisms and protein-ligand interactions in biochemical assays.
• Academic & Institutional Research: Utilized in university and government labs for fundamental research in organic chemistry, isotope chemistry, and medicinal chemistry.

Basic Information

Product Name	4-Chloro-6-Methoxy-2-Methyl-n-(4,4,5,5-Tetradeuterio-1H-Imidazol-2-Yl)Pyrimidin-5-Amine
CAS No.	1794811-52-1
Molecular Formula	C9H7D4ClN6O
Molecular Weight	254.70 g/mol
Synonyms	4-Chloro-6-methoxy-2-methyl-N-(4,4,5,5-tetradeuterio-1H-imidazol-2-yl)pyrimidin-5-amine; 2-(4-Chloro-6-methoxy-2-methylpyrimidin-5-yl)amino-4,5-dideuterio-1H-imidazole; Deuterated Imidazolylpyrimidine Amine; 4,4,5,5-Tetradeuterio-1H-imidazol-2-amine derivative; (4,4,5,5-2H4)-1H-Imidazol-2-amine, N-(4-chloro-6-methoxy-2-methyl-5-pyrimidinyl)-; CAS 1794811-52-1
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Methoxy-2-Methyl-n-(4,4,5,5-Tetradeuterio-1H-Imidazol-2-Yl)Pyrimidin-5-Amine is manufactured under strict quality control protocols to ensure the high purity and isotopic enrichment required for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic purity (D-content by NMR or MS), and impurity profiles. We adhere to cGMP principles for the production of advanced pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.