Description

2-[Methyl[5-(Phenylmethoxy)-2-Pyridinyl]Amino] Ethanol-D4 is a deuterated analog of a key pharmaceutical intermediate, where four hydrogen atoms are replaced with deuterium, a stable isotope. This deuteration is strategically employed to alter the metabolic profile of active pharmaceutical ingredients, potentially enhancing their efficacy, safety, and pharmacokinetic properties. This high-purity compound is essential for researchers and manufacturers in pharmaceutical development, particularly for those working on deuterated drug candidates, metabolic studies, and advanced isotope labeling applications.

Application

• Deuterated Drug Synthesis: A critical building block for the research and development of deuterium-labeled pharmaceutical compounds, leveraging the kinetic isotope effect.
• Metabolic Pathway Tracing: Used as a stable isotope-labeled internal standard in mass spectrometry for precise quantification and metabolic studies.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key intermediate in the synthesis of novel, patent-protected therapeutic agents.
• Pharmacokinetics & Drug Metabolism (DMPK) Research: Enables detailed investigation of absorption, distribution, metabolism, and excretion (ADME) profiles.
• Isotope-Labeled Reference Standards: Manufacture of certified reference materials (CRMs) for analytical method development and validation in regulatory environments.
• Biochemical Research: Tool compound for probing enzyme mechanisms and biological pathways where hydrogen transfer is involved.

Basic Information

Product Name	2-[Methyl[5-(Phenylmethoxy)-2-Pyridinyl]Amino] Ethanol-D4
CAS No.	1794786-87-0
Molecular Formula	C15H14D4N2O2
Molecular Weight	262.35 g/mol (approx.)
Synonyms	5-(Benzyloxy)-2-[(2-hydroxyethyl-D4)(methyl)amino]pyridine; 2-[[5-(Benzyloxy)-2-pyridinyl]methylamino]ethanol-D4; Deutetrabenazine Intermediate-D4; (2-Hydroxyethyl-D4)(methyl)[5-(phenylmethoxy)-2-pyridinyl]amine; SD-809 Deuterated Precursor; Tetradeuterated 2-[Methyl[5-(Phenylmethoxy)-2-Pyridinyl]Amino]Ethanol; VMAT2 Inhibitor Intermediate-D4; N-Methyl-N-(5-(benzyloxy)pyridin-2-yl)-2-aminoethanol-D4
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements of pharmaceutical R&D. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), isotopic enrichment (D-content by 1H NMR or MS), and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with client-specific pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.