Description

3,4,6-Trideuterio-5-(2,2-Dideuterio-1,2-Dihydroxyethyl)Benzene-1,2-Diol is a deuterated derivative of a key catechol structure, offering enhanced stability and unique spectroscopic properties for advanced research applications. This compound is critical for use as an internal standard or a labeled precursor in analytical chemistry and metabolic studies, where precise tracking and quantification are paramount. It is primarily utilized by pharmaceutical R&D laboratories, analytical service providers, and academic institutions engaged in drug discovery, pharmacokinetics, and stable isotope labeling.

Application

• Internal Standard for Mass Spectrometry (MS): Used in quantitative LC-MS and GC-MS analysis for accurate measurement of its non-deuterated counterpart in complex biological matrices.
• Stable Isotope-Labeled Tracer: Serves as a deuterium-labeled tracer in metabolic pathway studies and drug metabolism research (DMPK).
• Pharmaceutical Intermediate: Acts as a specialized building block for the synthesis of deuterated drug candidates, potentially improving metabolic stability.
• NMR Spectroscopy: Provides a valuable tool for mechanistic studies and structural analysis due to the distinct NMR signals of deuterium atoms.
• Biochemical Research: Employed in enzymatic studies to investigate reaction mechanisms involving catechol structures.
• Reference Material: Functions as a high-purity certified reference material (CRM) for method development and validation in analytical laboratories.

Basic Information

Item	Detail
Product Name	3,4,6-Trideuterio-5-(2,2-Dideuterio-1,2-Dihydroxyethyl)Benzene-1,2-Diol
CAS No.	1794783-36-0
Molecular Formula	C8H5D5O4
Molecular Weight	171.20 g/mol (for predominant isotopologue)
Synonyms	3,4,6-Trideuterio-5-(2,2-dideuterio-1,2-dihydroxyethyl)benzene-1,2-diol; Deuterated DOPAC; [D5]-DOPAC; 3,4-Dihydroxy-D5-phenethylglycol; 3,4-Dihydroxyphenyl-D5-ethanol glycol; (2,2,3',4',6'-Pentadeuterio-3,4-Dihydroxyphenyl)ethylene Glycol; D5-3,4-DHPE; Labeled Catechol Metabolite
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization via NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment (D%), and solvent content to ensure consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry place. This product is hygroscopic and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.