Description

Cilomilast-D9 is a deuterated analog of the selective phosphodiesterase-4 (PDE4) inhibitor Cilomilast, specifically labeled with nine deuterium atoms. This stable isotope-labeled compound is an essential tool for precise pharmacokinetic and metabolic studies, providing superior analytical sensitivity and accuracy. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and bioanalytical research for respiratory and inflammatory conditions.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in quantitative bioanalysis (LC-MS/MS) for the accurate measurement of Cilomilast in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Metabolite Identification: Aids in the structural elucidation and quantification of drug metabolites due to its predictable mass shift.
• Clinical Trial Support: Enables reliable and GLP-compliant bioanalytical data generation during preclinical and clinical development phases.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in regulatory submissions.
• Quality Control Reference: Can be used as a certified reference material in quality control laboratories to ensure assay accuracy.

Basic Information

Product Name	Cilomilast-D9
CAS No.	1794779-92-2
Molecular Formula	C20H16D9N3O4
Molecular Weight	~ 377.48 g/mol
Synonyms	Ariflo-D9; SB-207499-D9; 4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid-D9; [2H9]-Cilomilast; Cilomilast (deuterated); PDE4 Inhibitor-D9; Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (2H9)-
EINECS	Contact for details

Quality Control

Our Cilomilast-D9 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment, meeting the stringent requirements for analytical reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0% (by NMR)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.