Description

Chlorpropamide-D4 CAS NO 1794779-79-5 is a deuterated internal standard of the first-generation sulfonylurea drug, chlorpropamide. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analysis in pharmaceutical research and clinical diagnostics. It is primarily used by analytical chemists and researchers in pharmaceutical development, contract research organizations (CROs), and forensic toxicology laboratories for method development, validation, and precise quantification.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of chlorpropamide in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion in clinical and pre-clinical trials.
• Therapeutic Drug Monitoring (TDM): Used in clinical laboratories to monitor chlorpropamide concentrations in diabetic patients to ensure therapeutic efficacy and avoid toxicity.
• Metabolite Identification and Profiling: Aids in the identification and quantification of chlorpropamide metabolites in metabolism studies.
• Forensic and Toxicology Analysis: Provides a reliable reference for confirming and quantifying chlorpropamide in cases of overdose or post-mortem investigations.
• Method Development and Validation: Essential for developing robust, sensitive, and specific analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability testing of chlorpropamide drug substances and products.

Basic Information

Product Name	Chlorpropamide-D4
CAS No.	1794779-79-5
Molecular Formula	C10H9D4ClN2O3S
Molecular Weight	279.75 g/mol (deuterated form)
Synonyms	1-[(p-Chlorophenyl)sulfonyl]-3-propylurea-d4; 4-Chloro-N-[(propylamino)carbonyl]benzenesulfonamide-d4; Chlorpropamide (phenyl-d4); Chlorpropamide-d4 Internal Standard; N-(Propylcarbamoyl)-4-chlorobenzenesulfonamide-d4; N-Propyl-N'-(p-chlorobenzenesulfonyl)urea-d4; Diabinese-d4 (labeled analog)
EINECS	Contact for details

Quality Control

Our Chlorpropamide-D4 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment (typically ≥98 atom % D) and chemical purity (≥95%). Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic content are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (by difference)	≥ 97%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.