Description

1-[2-(2-Methoxyphenoxy)Ethylamino]-3-[9-(Trideuteriomethyl)Carbazol-4-Yl]Oxypropan-2-Ol:Hydrochloride is a deuterated carbazole derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a high-value synthetic intermediate or active pharmaceutical ingredient (API) precursor, where its deuterated methyl group can enhance metabolic stability and pharmacokinetic profiles. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the discovery of novel therapeutics, particularly for neurological and cardiovascular applications.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of deuterated drug candidates, leveraging the kinetic isotope effect for improved drug properties.
• Metabolic Studies: Used as a labeled standard or probe in drug metabolism and pharmacokinetics (DMPK) research to track compound fate in biological systems.
• Receptor Ligand Research: Applied in biochemical assays to study interactions with adrenergic or other G-protein coupled receptors due to its structural motifs.
• Preclinical Development: Employed in the formulation and testing of new chemical entities (NCEs) during early-stage drug development pipelines.
• Chemical Biology Tool: Utilized to investigate biological pathways and enzyme mechanisms where a deuterated probe is advantageous.
• Reference Standard: Acts as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	1-[2-(2-Methoxyphenoxy)Ethylamino]-3-[9-(Trideuteriomethyl)Carbazol-4-Yl]Oxypropan-2-Ol:Hydrochloride
CAS No.	1794766-62-3
Molecular Formula	C25H28D3ClN2O4
Molecular Weight	~473.96 g/mol
Synonyms	Carvedilol-d3 Impurity; 9-(Trideuteriomethyl)-4-({3-[(2-(2-methoxyphenoxy)ethyl)amino]-2-hydroxypropoxy})-9H-carbazole Hydrochloride; Carbazol-4-ol, 9-(trideuteriomethyl)-, 4-[3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-hydroxypropyl] ether, hydrochloride; Deuterated Carvedilol Related Compound; 1-{2-[(2-Methoxyphenoxy)ethyl]amino}-3-{[9-(trideuteriomethyl)-9H-carbazol-4-yl]oxy}-2-propanol Hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 1-[2-(2-Methoxyphenoxy)Ethylamino]-3-[9-(Trideuteriomethyl)Carbazol-4-Yl]Oxypropan-2-Ol:Hydrochloride is characterized and released with a comprehensive Certificate of Analysis (COA). We adhere to strict in-house specifications aligned with ICH guidelines, ensuring identity, purity, and strength. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Deuteration Degree (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.