Description

1-(Trideuteriomethyl)-4-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine is a deuterated piperazine derivative, a high-value building block designed for advanced research and development. Its core value lies in the strategic incorporation of deuterium, which can significantly alter the metabolic profile and stability of target molecules, making it a critical tool in the development of new pharmaceuticals and agrochemicals. This compound is essential for medicinal chemists, process development scientists, and analytical laboratories working in drug discovery, metabolic studies, and the synthesis of isotopically labeled standards.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Deuterated Active Pharmaceutical Ingredient (API) Development: Used to create deuterium-labeled versions of existing drugs to potentially improve pharmacokinetics (PK), pharmacodynamics (PD), and reduce metabolite-related toxicity.
• Metabolic Pathway Tracing: Serves as a precursor for synthesizing internal standards used in Liquid Chromatography-Mass Spectrometry (LC-MS) for accurate bioanalysis and drug metabolism studies.
• Agrochemical Research: Employed in the development of new, more stable, and effective crop protection agents with potentially enhanced environmental profiles.
• Chemical Biology Probes: Useful for creating labeled probes to study enzyme mechanisms and protein-ligand interactions in complex biological systems.
• Process Chemistry & Scale-Up: Provides a route for introducing deuterium at a late stage in synthetic pathways, aiding in the optimization of manufacturing processes for deuterated compounds.

Basic Information

Product Name	1-(Trideuteriomethyl)-4-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine
CAS No.	1794760-10-3
Molecular Formula	C16H24D3N2O3
Molecular Weight	295.41 g/mol
Synonyms	4-[(2,3,4-Trimethoxyphenyl)methyl]-1-(trideuteriomethyl)piperazine; 1-(Methyl-d3)-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine; (2,3,4-Trimethoxybenzyl)-1-(methyl-d3)-piperazine; Deuterated Trimethoprim Intermediate; d3-Trimethoprim Precursor; N-(Trideuteriomethyl)-N'-[(2,3,4-trimethoxyphenyl)methyl]piperazine; Piperazine, 1-(trideuteriomethyl)-4-[(2,3,4-trimethoxyphenyl)methyl]-
EINECS	Contact for details

Quality Control

Our 1-(Trideuteriomethyl)-4-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored away from direct light and moisture to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.