Description

2-[4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethanol-D4 is a deuterated analog of a key pharmaceutical intermediate, where four hydrogen atoms are replaced with deuterium. This deuteration is strategically employed to alter the metabolic profile of active compounds, enhancing stability and extending their half-life in biological systems. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating deuterated drug candidates and for use as an internal standard in advanced analytical techniques like LC-MS.

Application

• Deuterated Drug Development: A critical building block for synthesizing novel active pharmaceutical ingredients (APIs) where deuterium substitution is used to improve pharmacokinetic properties.
• Metabolic Studies: Serves as a stable isotope-labeled tracer in drug metabolism and pharmacokinetics (DMPK) research to track and quantify metabolic pathways.
• Analytical Reference Standard: Used as a high-purity internal standard in mass spectrometry (LC-MS, GC-MS) for the accurate quantification of its non-deuterated counterpart in complex matrices.
• Biochemical Research: Employed in mechanistic studies to investigate enzyme activity and receptor-ligand interactions where isotopic labeling is required.
• Process Chemistry & Scale-up: Supports process development and optimization for the manufacture of deuterated pharmaceuticals at various scales.

Basic Information

Product Name	2-[4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethanol-D4
CAS No.	1794756-21-0
Molecular Formula	C19H19D4ClN2O
Molecular Weight	~330.88 g/mol
Synonyms	1-(2-Hydroxyethyl)-4-[(4-chlorophenyl)phenylmethyl]piperazine-d4; Cetirizine-d4 Impurity; (4-Chlorobenzhydryl)-1-piperazineethanol-d4; 2-[4-[(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethan-1,1,2,2-d4-ol; Deuterated Hydroxyzine/Cetirizine Metabolite Intermediate; Zyrtec Related Compound-d4
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C) and high-resolution mass spectrometry to confirm deuteration level and identity. Certificates of Analysis (COA) are provided, detailing purity, isotopic enrichment, and results from all specified tests, ensuring traceability and compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.