Description

1-[2-[4-[5-Chloro-1-(4-Fluorophenyl)Indol-3-Yl]Piperidin-1-Yl]-1,1,2,2-Tetradeuterioethyl]Imidazolidin-2-One is a deuterated organic compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its utility as a stable isotope-labeled intermediate or reference standard, enabling critical studies in drug metabolism, pharmacokinetics (DMPK), and bioanalytical method development. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise tools for tracing molecular pathways and ensuring regulatory compliance in new drug applications.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of its non-deuterated counterpart in drug substance and product analysis.
• Metabolic Tracing Studies: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to study the Absorption, Distribution, Metabolism, and Excretion (ADME) profile of lead compounds.
• Deuterated Drug Intermediate: Acts as a key synthetic building block in the development of deuterium-labeled active pharmaceutical ingredients (APIs), which can offer improved metabolic stability.
• Bioanalytical Research: Employed in method development and validation to ensure accuracy, precision, and specificity in complex biological matrices like plasma and serum.
• Isotope Dilution Mass Spectrometry (IDMS): Provides high-accuracy results in quantitative analysis, crucial for clinical research and regulatory submissions.
• Chemical Biology Probes: Utilized in mechanistic studies to elucidate biological pathways and target engagement without significantly altering the molecule's biological activity.

Basic Information

Product Name	1-[2-[4-[5-Chloro-1-(4-Fluorophenyl)Indol-3-Yl]Piperidin-1-Yl]-1,1,2,2-Tetradeuterioethyl]Imidazolidin-2-One
CAS No.	1794737-42-0
Molecular Formula	C24H23D4ClFN3O
Molecular Weight	427.97 g/mol (for the deuterated form)
Synonyms	1-[2-[4-[5-Chloro-1-(4-Fluorophenyl)-1H-Indol-3-Yl]-1-Piperidinyl]-1,1,2,2-tetradeuterioethyl]-2-Imidazolidinone; 1-[2-[4-[5-Chloro-1-(4-Fluorophenyl)Indol-3-Yl]Piperidin-1-Yl]-1,1,2,2-D4-ethyl]imidazolidin-2-one; Deuterated Imidazolidinone Derivative; 5-Chloro-1-(4-fluorophenyl)-3-[1-[2-(2-oxoimidazolidin-1-yl)-1,1,2,2-d4-ethyl]piperidin-4-yl]indole; CAS 1794737-42-0; Stable Isotope-Labeled Indole-Piperidine-Imidazolidinone Conjugate
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ²H), High-Resolution Mass Spectrometry (HRMS), and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as chemical purity, isotopic enrichment (D-content), and impurity profile, supporting compliance with research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/LC-MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.