Description

2-Amino-3-(Methyl-D3-Amino)-Propionic Acid Hydrochloride is a deuterated amino acid derivative, specifically a hydrochloride salt of a methyl-D3-labeled alanine analog. This compound is a critical stable isotope-labeled building block, enabling advanced research in metabolic studies and drug development where precise molecular tracking is required. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on proteomics, pharmacokinetics, and the synthesis of novel therapeutic agents.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a stable isotope-labeled internal standard in quantitative bioanalytical methods for accurate measurement of amino acids or related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Serves as a deuterium-labeled tracer in mass spectrometry-based studies to investigate amino acid metabolism, protein turnover, and metabolic flux.
• Pharmaceutical Intermediate: Acts as a key chiral synthon in the research and development of deuterated drug candidates, potentially enhancing metabolic stability and pharmacokinetic profiles.
• Proteomics Research: Employed in stable isotope labeling by amino acids in cell culture (SILAC) and other quantitative proteomics techniques for comparative protein analysis.
• Biochemical Research Reagent: Used in enzymatic studies and as a substrate or inhibitor in research concerning amino acid transporters and metabolic enzymes.

Basic Information

Product Name	2-Amino-3-(Methyl-D3-Amino)-Propionic Acid Hydrochloride
CAS No.	1794713-10-2
Molecular Formula	C4H8D3ClN2O2
Molecular Weight	154.60 g/mol
Synonyms	L-Alanine-3-methyl-d3 hydrochloride; (2S)-2-Amino-3-[(methyl-d3)amino]propanoic acid hydrochloride; 3-(Methyl-d3-amino)-L-alanine hydrochloride; Deuterated L-Alanine derivative hydrochloride; Methyl-D3-labeled alanine hydrochloride; Amino acid-d3 HCl salt; 2-Amino-3-((methyl-d3)amino)propanoic acid HCl
EINECS	Contact for details

Quality Control

Our 2-Amino-3-(Methyl-D3-Amino)-Propionic Acid Hydrochloride is produced under controlled conditions to ensure high isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.