Description

Methyl 5-Bromoindoline-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex indoline-based drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its brominated indoline structure for biological activity.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing more elaborate molecular architectures.
• Material Science Research: Investigated as a monomer or precursor for functional organic materials and dyes due to its conjugated system.
• Academic & R&D Laboratories: Serves as a standard reagent for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	Methyl 5-Bromoindoline-6-Carboxylate
CAS No.	1788041-64-4
Molecular Formula	C10H10BrNO2
Molecular Weight	256.10 g/mol
Synonyms	6-Carbomethoxy-5-bromoindoline; Methyl 5-bromo-2,3-dihydro-1H-indole-6-carboxylate; 5-Bromo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester; 5-Bromoindoline-6-carboxylic Acid Methyl Ester; 5-Bromo-6-(methoxycarbonyl)indoline; CAS 1788041-64-4
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromoindoline-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.