Description

(S)-1-(6-Chloro-5-Fluoro-1H-Indol-3-Yl)Propan-2-Amine Hydrochloride is a high-purity chiral indole derivative, specifically designed as a critical building block for advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate, enabling the creation of novel therapeutic agents with precise stereochemistry. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Biochemical Tool Compound: Potential use in the development of pharmacological probes for studying specific biological pathways and receptor interactions.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and the construction of complex molecules requiring the (S)-configured amine moiety.

Basic Information

Product Name	(S)-1-(6-Chloro-5-Fluoro-1H-Indol-3-Yl)Propan-2-Amine Hydrochloride
CAS No.	1788036-24-7
Molecular Formula	C11H13ClF N2 • HCl
Molecular Weight	261.10 (Free base) / 297.56 (Hydrochloride salt)
Synonyms	(S)-1-(6-Chloro-5-fluoro-1H-indol-3-yl)propan-2-amine hydrochloride; (S)-6-Chloro-5-fluoro-3-(2-aminopropyl)-1H-indole hydrochloride; (S)-1-(6-Chloro-5-fluoro-1H-indol-3-yl)-2-propylamine hydrochloride; (S)-1-(6-Chloro-5-fluoro-indol-3-yl)-propan-2-amine HCl; (S)-3-(2-Aminopropyl)-6-chloro-5-fluoro-1H-indole hydrochloride; 1788036-24-7
EINECS	Contact for details

Quality Control

Our (S)-1-(6-Chloro-5-Fluoro-1H-Indol-3-Yl)Propan-2-Amine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 quality management principles, and material can be supplied to meet specific customer requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.