Description

(S)-5-Fluoro-2-(Pyrrolidin-3-Yl)Isoindolin-1-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant interest in modern drug discovery. This compound is valued for its unique structural motif, which combines a fluorinated isoindolinone core with a pyrrolidine moiety, making it a versatile scaffold for medicinal chemistry. It is primarily utilized by research organizations and pharmaceutical companies engaged in the development of novel therapeutics, particularly for central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the synthesis of linker-warhead conjugates for targeted protein degradation platforms.
• CNS Drug Discovery: Employed in the synthesis of potential therapeutics targeting neurological and psychiatric conditions.
• Kinase Inhibitor Synthesis: A building block for the creation of novel small-molecule kinase inhibitors for oncology research.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Serves as a critical intermediate during the route scouting and optimization phases for API manufacturing.

Basic Information

Product Name	(S)-5-Fluoro-2-(Pyrrolidin-3-Yl)Isoindolin-1-One Hydrochloride
CAS No.	1786969-20-7
Molecular Formula	C₁₂H₁₄ClFN₂O
Molecular Weight	256.70 g/mol
Synonyms	1H-Isoindol-1-one, 5-fluoro-2-[(3S)-3-pyrrolidinyl]-, hydrochloride (1:1); (S)-5-Fluoro-2-(3-pyrrolidinyl)-1H-isoindol-1-one hydrochloride; (S)-5-Fluoro-2-(pyrrolidin-3-yl)isoindolin-1-one HCl; (S)-5-Fluoro-2-(3-pyrrolidinyl)isoindolin-1-one hydrochloride; (S)-5-Fluoro-2-(pyrrolidin-3-yl)-2,3-dihydro-1H-isoindol-1-one hydrochloride; 5-Fluoro-2-[(3S)-3-pyrrolidinyl]-1H-isoindol-1-one hydrochloride; CAS 1786969-20-7
EINECS	Contact for details

Quality Control

Our (S)-5-Fluoro-2-(Pyrrolidin-3-Yl)Isoindolin-1-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.