Description

(S)-7-Fluoro-2-(Pyrrolidin-3-Yl)Isoindolin-1-One Hydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a component for constructing linker-warhead systems due to its specific stereochemistry and functional groups.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitor scaffolds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Academic & Institutional Research: Used in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	(S)-7-Fluoro-2-(Pyrrolidin-3-Yl)Isoindolin-1-One Hydrochloride
CAS No.	1786749-99-2
Molecular Formula	C12H14ClFN2O
Molecular Weight	256.70 g/mol
Synonyms	(S)-7-Fluoro-2-(3-pyrrolidinyl)isoindolin-1-one hydrochloride; 1H-Isoindol-1-one, 7-fluoro-2-[(3S)-3-pyrrolidinyl]-, hydrochloride (1:1); (3S)-7-Fluoro-2-(pyrrolidin-3-yl)isoindolin-1-one HCl; (S)-7-Fluoro-2-(3-pyrrolidinyl)-1-isoindolinone hydrochloride; 1786749-99-2; (S)-7-Fluoro-2-(pyrrolidin-3-yl)isoindolin-1-one hydrochloride salt
EINECS	Contact for details

Quality Control

Our (S)-7-Fluoro-2-(Pyrrolidin-3-Yl)Isoindolin-1-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.