Description

2-Chloro-3,4-Difluorobenzyl Alcohol is a versatile fluorinated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine substituents, which allow for precise structural modifications and tuning of electronic properties in target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluorobenzyl moiety enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Organic Electronics: Building block for synthesizing charge-transport materials and fluorinated polymers used in OLEDs and semiconductor layers.
• Cross-Coupling Reactions: The benzyl alcohol group can be functionalized or used in palladium-catalyzed coupling reactions to construct complex biaryl structures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and material science research exploring structure-activity relationships (SAR).

Basic Information

Product Name	2-Chloro-3,4-Difluorobenzyl Alcohol
CAS No.	1784873-93-3
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	(2-Chloro-3,4-difluorophenyl)methanol; 3,4-Difluoro-2-chlorobenzyl Alcohol; 2-Chloro-3,4-difluorobenzenemethanol; 1-(Chloro)-2,3-difluoro-4-(hydroxymethyl)benzene; α-Hydroxy-2-chloro-3,4-difluorotoluene; Benzenemethanol, 2-chloro-3,4-difluoro-; 2-Chloro-α,3,4-trifluorobenzyl Alcohol (incorrect but common search variant)
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,4-Difluorobenzyl Alcohol is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent composition. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.