Description

Isoquinoline, 3,4-Dihydro-6,7-Di(Methoxy-D3)-, Hydrochloride (1:1) is a deuterated derivative of a tetrahydroisoquinoline alkaloid, specifically designed for advanced research and development applications. This compound is valued for its role as a stable isotope-labeled internal standard or precursor in analytical chemistry and metabolic studies. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and chemical manufacturers engaged in drug discovery, pharmacokinetics, and the synthesis of novel bioactive molecules.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard in quantitative bioanalysis for accurate measurement of parent compounds in biological matrices.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to investigate metabolic stability and identify metabolites.
• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in pharmaceutical analysis.
• Precursor for Deuterated APIs: Acts as a key synthetic intermediate in the development of deuterium-labeled active pharmaceutical ingredients (APIs) for enhanced metabolic properties.
• Neuroscience Research: Investigated for its potential interactions with neurological receptors due to its tetrahydroisoquinoline core structure.
• Isotope Dilution Mass Spectrometry (IDMS): Critical for achieving high accuracy and precision in quantitative assays across clinical and forensic toxicology.

Basic Information

Product Name	Isoquinoline, 3,4-Dihydro-6,7-Di(Methoxy-D3)-, Hydrochloride (1:1)
CAS No.	1783808-87-6
Molecular Formula	C12H12D6ClNO2
Molecular Weight	259.78 g/mol
Synonyms	6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-d6 hydrochloride; 6,7-Bis(methoxy-d3)-1,2,3,4-tetrahydroisoquinoline hydrochloride; Deuterated THIQ hydrochloride; 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-6,7-di(methoxy-d3) hydrochloride; (6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-6,7-diyl)bis(methanol-d3) hydrochloride; 1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline-d6 HCl; 6,7-Di(methoxy-d3)-1,2,3,4-tetrahydroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under strict quality management systems to ensure isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic enrichment (D-content), and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.