Description

2-Bromo-4-Chloro-3-Fluoro-1-Methyl-Benzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers seeking to introduce specific halogen functionalities into target structures, enabling the fine-tuning of biological activity and material properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the halogen atoms contribute to binding affinity and metabolic stability.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and advanced polymers requiring specific electronic and steric properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromo and chloro substituents.
• Fluorine Chemistry: The presence of the fluorine atom makes it valuable for creating compounds with enhanced bioavailability, lipophilicity, and metabolic resistance.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-Bromo-4-Chloro-3-Fluoro-1-Methyl-Benzene
CAS No.	1782385-65-2
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-Bromo-3-chloro-2-fluoro-4-methylbenzene; 4-Chloro-3-fluoro-2-bromotoluene; 2-Bromo-4-chloro-3-fluorotoluene; Toluene, 2-bromo-4-chloro-3-fluoro-; Benzene, 2-bromo-4-chloro-3-fluoro-1-methyl-; 3-Fluoro-2-bromo-4-chlorotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Chloro-3-Fluoro-1-Methyl-Benzene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.