Description

6-Bromo-5-Fluoro-1,2,3,4-Tetrahydroisoquinoline is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs). This compound is critically needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce halogenated motifs for enhanced bioactivity and material properties. The CAS number for this compound is 1781658-50-1.

Application

This specialized intermediate serves as a key precursor in several high-growth research and industrial areas:

• Pharmaceutical Intermediate: A crucial building block for synthesizing potential drug candidates, especially in central nervous system (CNS) and oncology research pipelines.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, leveraging the fluorine and bromine substituents for improved efficacy.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its nitrogen-containing heterocyclic structure.
• Material Science Research: Acts as a monomer or functionalizing agent in the synthesis of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	6-Bromo-5-Fluoro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1781658-50-1
Molecular Formula	C9H9BrFN
Molecular Weight	230.08 g/mol
Synonyms	5-Fluoro-6-bromo-1,2,3,4-tetrahydroisoquinoline; 6-Bromo-5-fluoro-3,4-dihydro-1H-isoquinoline; 1,2,3,4-Tetrahydro-6-bromo-5-fluoro-isoquinoline; 5-Fluoro-6-bromotetrahydroisoquinoline; 6-Br-5-F-THIQ; BFTHIQ; 1781658-50-1
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-Fluoro-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to light and potential reactivity with strong bases, ensure the container is kept sealed and separated from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.