Description

4-Bromo-1-Methyl-3-(Trifluoromethyl)-1H-Indazole is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a bromo-substituent and a trifluoromethyl group on the indazole scaffold, enabling precise molecular modifications. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients. Its unique structure facilitates key reactions like cross-coupling, making it an essential intermediate for creating targeted libraries of bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and inflammation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or functionalizing agent for advanced polymers and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions to construct complex molecular architectures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Ligand Synthesis: Employed in the creation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Bromo-1-Methyl-3-(Trifluoromethyl)-1H-Indazole
CAS No.	1781580-84-4
Molecular Formula	C9H6BrF3N2
Molecular Weight	279.06 g/mol
Synonyms	4-Bromo-1-methyl-3-(trifluoromethyl)-1H-indazole; 1-Methyl-4-bromo-3-(trifluoromethyl)indazole; 4-Bromo-1-methyl-3-trifluoromethyl-1H-indazole; 1H-Indazole, 4-bromo-1-methyl-3-(trifluoromethyl)-; 1781580-84-4
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Methyl-3-(Trifluoromethyl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to consistent quality and traceability supports critical R&D and scale-up processes for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.