Description

4-Bromo-8-(Trifluoromethyl)Isoquinoline is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters because it combines a reactive bromo substituent with a stable trifluoromethyl group, offering unique electronic properties and serving as a critical precursor for creating complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications in drug discovery, ligand design, and the development of functional organic materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of new generation herbicides and pesticides, leveraging the biological activity of the isoquinoline scaffold.
• Material Science Precursor: Acts as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other advanced electronic materials due to its electron-deficient character.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl or alkynyl groups.
• Ligand Synthesis: Utilized in the preparation of specialized nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: The trifluoromethyl group makes it a valuable compound for studying the effects of fluorine incorporation on physicochemical properties.

Basic Information

Product Name	4-Bromo-8-(Trifluoromethyl)Isoquinoline
CAS No.	1780593-58-9
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	4-Bromo-8-(trifluoromethyl)isoquinoline; 8-(Trifluoromethyl)-4-bromoisoquinoline; 4-Bromo-8-trifluoromethylisoquinoline; Isoquinoline, 4-bromo-8-(trifluoromethyl)-; 1780593-58-9
EINECS	Contact for details

Quality Control

Our 4-Bromo-8-(Trifluoromethyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark place to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.