Description

7-Bromo-4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for introducing specific pharmacophores and modifying physicochemical properties in target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the difluoro and bromo groups can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing advanced organic materials, such as liquid crystals, organic semiconductors, and functional polymers with tailored electronic properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological processes and target engagement, leveraging its halogen atoms for further functionalization.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	7-Bromo-4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1780338-53-5
Molecular Formula	C9H8BrF2N
Molecular Weight	248.07 g/mol
Synonyms	7-Bromo-4,4-difluoro-1,2,3,4-tetrahydroisoquinoline; 4,4-Difluoro-7-bromo-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-bromo-4,4-difluoro-isoquinoline; 7-Bromo-4,4-difluoro-3,4-dihydro-1H-isoquinoline; 1780338-53-5; AI3-32855; ZINC000644019689
EINECS	Contact for details

Quality Control

Every batch of 7-Bromo-4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.