Description

2-((2S,3S)-3-(tert-Butyl)-4-Methoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)-6-Methoxypyridine is a sophisticated chiral organophosphorus compound, serving as a critical intermediate in advanced pharmaceutical synthesis and asymmetric catalysis. Its unique bicyclic oxaphosphole structure provides a rigid, stereodefined scaffold essential for constructing complex molecules with high enantiomeric purity. This high-value building block is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Asymmetric Catalysis: Employed as a precursor or a ligand in transition metal catalysis for enantioselective C-C and C-X bond-forming reactions.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new synthetic methodologies and constructing complex molecular architectures.
• Agrochemical Synthesis: Potential application as an intermediate in the development of advanced, stereospecific pesticides and herbicides.
• Material Science: Investigation into its use for creating novel chiral polymers or functional materials with specific optical properties.

Basic Information

Product Name	2-((2S,3S)-3-(tert-Butyl)-4-Methoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)-6-Methoxypyridine
CAS No.	1777796-37-8
Molecular Formula	C19H24NO3P
Molecular Weight	345.37 g/mol
Synonyms	(2S,3S)-3-(tert-Butyl)-2-(6-methoxypyridin-2-yl)-4-methoxy-2,3-dihydrobenzo[d][1,3]oxaphosphole; 2-[(2S,3S)-3-tert-Butyl-4-methoxy-2,3-dihydro-1,3-benzoxaphosphol-2-yl]-6-methoxypyridine; Chiral Oxaphosphole-Pyridine Ligand Intermediate; (2S,3S)-3-tert-Butyl-4-methoxy-2-(6-methoxypyridin-2-yl)-2,3-dihydro-1,3-benzoxaphosphole
EINECS	Contact for details

Quality Control

Our production of 2-((2S,3S)-3-(tert-Butyl)-4-Methoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)-6-Methoxypyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, critical for pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation. Our quality system is designed to meet the rigorous standards of cGMP for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.