Description

(1R,2S,3S,4S)-3-(Ethoxycarbonyl)Bicyclo[2.2.2]Oct-5-Ene-2-Carboxylicacid CAS NO 1777721-52-4 is a high-purity, stereochemically defined bicyclic compound that serves as a critical chiral building block in advanced organic synthesis. Its rigid, functionalized structure makes it an invaluable intermediate for constructing complex molecular architectures with precise three-dimensional control. This product is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and other therapeutic areas requiring complex stereochemistry.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the specific stereochemistry can influence biological activity and environmental profile.
• Asymmetric Catalysis Ligand Precursor: The carboxylic acid and ester functionalities provide handles for derivatization into novel chiral ligands or organocatalysts.
• Material Science Research: Serves as a building block for novel polymers or organic frameworks where the bicyclo[2.2.2]octane core imparts rigidity and specific spatial geometry.
• Academic & Industrial R&D: A valuable tool for synthetic chemists in universities and corporate labs exploring new reaction methodologies and constructing complex natural product analogs.

Basic Information

Item	Detail
Product Name	(1R,2S,3S,4S)-3-(Ethoxycarbonyl)Bicyclo[2.2.2]Oct-5-Ene-2-Carboxylic Acid
CAS No.	1777721-52-4
Molecular Formula	C13H16O4
Molecular Weight	236.26 g/mol
Synonyms	(1R,2S,3S,4S)-3-(Ethoxycarbonyl)bicyclo[2.2.2]oct-5-ene-2-carboxylic acid; (1R,2S,3S,4S)-rel-3-(Ethoxycarbonyl)bicyclo[2.2.2]oct-5-ene-2-carboxylic acid; Bicyclo[2.2.2]oct-5-ene-2-carboxylic acid, 3-(ethoxycarbonyl)-, (1R,2S,3S,4S)-; Ethyl (1R,2S,3S,4S)-2-carboxybicyclo[2.2.2]oct-5-ene-3-carboxylate; CAS 1777721-52-4
EINECS	Contact for details

Quality Control

Every batch of our (1R,2S,3S,4S)-3-(Ethoxycarbonyl)Bicyclo[2.2.2]Oct-5-Ene-2-Carboxylic Acid is produced under strict quality management protocols to ensure high chiral purity and chemical consistency. We employ advanced analytical techniques including chiral HPLC and NMR to verify identity, enantiomeric excess, and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.