Description

4-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged spirocyclic structure.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of specific enzymes like kinases or proteases relevant to disease pathways.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological targets and signaling pathways in cellular models.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for preclinical and clinical trials.

Basic Information

Product Name	4-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One
CAS No.	1713164-01-2
Molecular Formula	C12H13BrN2O
Molecular Weight	281.15 g/mol
Synonyms	4-Bromo-1,2-dihydrospiro[indole-3,4'-piperidin]-2-one; 4-Bromospiro[indole-3,4'-piperidine]-2(1H)-one; 4-Bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]; Spiro[indole-3,4'-piperidine]-2-one, 4-bromo-1,2-dihydro-; 1713164-01-2; 4-Bromo-spiro[indoline-3,4'-piperidin]-2-one
EINECS	Contact for details

Quality Control

Our 4-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.