Description

3-Cyclobutyl-4-Fluoro-1H-Indole is a high-value, fluorinated indole derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a cyclobutyl ring and a fluorine atom on the indole scaffold, enabling precise modulation of biological activity and physicochemical properties. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides, where the fluorine atom enhances bioavailability and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its rigid, planar structure.
• Chemical Biology Probes: Employed in the design of fluorescent tags and molecular probes for studying enzyme mechanisms and cellular processes.
• Academic & Contract Research: Essential for methodological studies in organic chemistry, including novel cycloaddition and cross-coupling reactions.

Basic Information

Product Name	3-Cyclobutyl-4-Fluoro-1H-Indole
CAS No.	1707361-87-2
Molecular Formula	C₁₂H₁₂FN
Molecular Weight	189.23 g/mol
Synonyms	4-Fluoro-3-cyclobutyl-1H-indole; 1H-Indole, 3-cyclobutyl-4-fluoro-; 3-Cyclobutyl-4-fluoroindole; 4-Fluoro-3-cyclobutylindole; FCB-Indole
EINECS	Contact for details

Quality Control

Our 3-Cyclobutyl-4-Fluoro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.