Description

5-Fluoro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic indole-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged spirocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential ligand or linker component in the design of novel bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Preclinical Development: Supplied for use in early-stage pharmacological and toxicological studies.

Basic Information

Product Name	5-Fluoro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride
CAS No.	1707361-59-8
Molecular Formula	C13H14ClFN2O
Molecular Weight	268.71 g/mol
Synonyms	5-Fluoro-1,2-dihydrospiro[indole-3,4'-piperidin]-2-one hydrochloride; 5-Fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine] hydrochloride; 5-Fluoro-1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine] hydrochloride; 5-Fluoro-1,2-dihydrospiro[3H-indole-3,4'-piperidin]-2-one HCl; 5-Fluoro-2-oxospiro[indoline-3,4'-piperidine] hydrochloride; 1707361-59-8; Spiro[indole-3,4'-piperidine]-2-one, 5-fluoro-1,2-dihydro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.