Description

(2S)-n-[4-[[3-Cyano-1-(2-Methylpropyl)-1H-Indol-5-Yl]Oxy]Phenyl]-2-Pyrrolidinecarboxamide is a high-purity, non-racemic chiral compound featuring a complex indole-pyrrolidinecarboxamide structure. This molecule is of significant interest in advanced pharmaceutical research and development, particularly as a key intermediate or active pharmaceutical ingredient (API) for targeted therapies. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel therapeutic agents, especially in oncology and central nervous system (CNS) drug discovery.
• Biochemical Research: Used as a reference standard or probe compound in pharmacological studies to investigate specific biological pathways and receptor interactions.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for the production of chiral active pharmaceutical ingredients (APIs).
• Preclinical Development: Utilized in the formulation of drug candidates for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Custom Synthesis: Acts as a starting material for the preparation of more complex, proprietary analogs and derivatives for specialized research programs.

Basic Information

Product Name	(2S)-n-[4-[[3-Cyano-1-(2-Methylpropyl)-1H-Indol-5-Yl]Oxy]Phenyl]-2-Pyrrolidinecarboxamide
CAS No.	1704740-52-2
Molecular Formula	C24H26N4O2
Molecular Weight	402.49 g/mol
Synonyms	(2S)-N-[4-[[3-Cyano-1-(2-methylpropyl)-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide; (2S)-N-(4-((3-Cyano-1-isobutyl-1H-indol-5-yl)oxy)phenyl)pyrrolidine-2-carboxamide; UNII-4Q2Q8T4Q1K; 4Q2Q8T4Q1K; (S)-N-(4-((3-Cyano-1-isobutyl-1H-indol-5-yl)oxy)phenyl)pyrrolidine-2-carboxamide; Aprepitant Impurity 46; (S)-Aprepitant Impurity F
EINECS	Contact for details

Quality Control

Every batch of (2S)-n-[4-[[3-Cyano-1-(2-Methylpropyl)-1H-Indol-5-Yl]Oxy]Phenyl]-2-Pyrrolidinecarboxamide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are characterized using advanced techniques including HPLC, NMR, and MS to meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.