Description

(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-3-Chlorophenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a spirocyclic ketal-protected diol and a chlorophenyl moiety, making it a valuable advanced pharmaceutical intermediate and building block for modern organic synthesis. Its primary value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl systems. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require high-purity, functionalized boronic acids for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex biaryl or heterobiaryl structures.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile coupling partner with aryl/heteroaryl halides to form carbon-carbon bonds under palladium catalysis, enabling the construction of complex molecules.
• Agrochemical Research: Serves as a key intermediate in the development of new herbicides, fungicides, and insecticides that require specific chlorinated biaryl motifs.
• Materials Science & OLED Development: Employed in the synthesis of organic semiconductors, ligands for metal-organic frameworks (MOFs), and emissive layers for organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates, leveraging the boronic acid group's ability to interact with diols and its utility in bioorthogonal chemistry.
• Catalyst & Ligand Synthesis: Acts as a precursor for synthesizing novel bidentate or tridentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Item	Details
Product Name	(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-3-Chlorophenyl)Boronic Acid
CAS No.	1704074-53-2
Molecular Formula	C16H21BClNO4
Molecular Weight	337.60 g/mol
Synonyms	3-Chloro-4-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzeneboronic acid; (3-Chloro-4-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)phenyl)boronic acid; 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-3-chlorobenzeneboronic acid; B-(3-Chloro-4-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)phenyl)boronic acid; 1704074-53-2; Spirocyclic-protected chlorophenylboronic acid
EINECS	Contact for details

Quality Control

Our (4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-3-Chlorophenyl)Boronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing all critical quality attributes. Our commitment to quality supports applications in GMP-intermediate synthesis and other demanding research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.