Description

3-(4-(tert-Butoxycarbonyl)Piperazin-1-Ylsulfonyl)-4-Methylphenylboronic Acid is a sophisticated boronic acid derivative featuring a piperazine sulfonamide core protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical high-value building block in modern pharmaceutical research, enabling the synthesis of complex molecules through reliable cross-coupling reactions. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel drug candidates, particularly in kinase inhibitor and protease inhibitor programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl structures central to many drug molecules.
• Protease Inhibitor Development: Used in the research and synthesis of compounds designed to inhibit specific protease enzymes.
• Kinase Inhibitor Libraries: Employed in the combinatorial chemistry and parallel synthesis of compound libraries for high-throughput screening against kinase targets.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supports route scouting and optimization from milligram to kilogram scale for clinical trial material production.

Basic Information

Product Name	3-(4-(tert-Butoxycarbonyl)Piperazin-1-Ylsulfonyl)-4-Methylphenylboronic Acid
CAS No.	1704066-78-3
Molecular Formula	C₁₇H₂₇BN₂O₆S
Molecular Weight	398.28 g/mol
Synonyms	Boc-Piperazine Sulfonamide Phenylboronic Acid; 4-Methyl-3-(4-((tert-butoxycarbonyl)piperazin-1-yl)sulfonyl)phenylboronic Acid; 3-(4-Boc-piperazine-1-sulfonyl)-4-methylbenzeneboronic Acid; 1-Boc-4-[(5-borono-2-methylphenyl)sulfonyl]piperazine; (3-((4-(tert-Butoxycarbonyl)piperazin-1-yl)sulfonyl)-4-methylphenyl)boronic Acid; CAS 1704066-78-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested to ensure identity, purity, and consistency suitable for research and development applications. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by NMR and IR), and impurity profiles are provided with each shipment. We support our clients' regulatory needs with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.