Description

Methyl 5-(Trifluoromethyl)-1,3-thiazole-4-carboxylate is a high-value trifluoromethylated heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the unique combination of the thiazole ring and the trifluoromethyl group, which imparts desirable properties like metabolic stability and enhanced lipophilicity to target molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its precise structure makes it a key intermediate for developing compounds with improved biological activity and patentability.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinases, GPCRs, and other biological targets.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the CF3-thiazole moiety can enhance activity and environmental profile.
• Material Science Research: Serves as a precursor for advanced organic materials, including liquid crystals, organic semiconductors, and functional polymers.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and biochemical tools for studying enzyme mechanisms and cellular processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in client-specific synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	Methyl 5-(Trifluoromethyl)-1,3-thiazole-4-carboxylate
CAS No.	1698908-74-5
Molecular Formula	C6H4F3NO2S
Molecular Weight	211.16 g/mol
Synonyms	5-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid methyl ester; Methyl 5-(trifluoromethyl)thiazole-4-carboxylate; 4-Thiazolecarboxylic acid, 5-(trifluoromethyl)-, methyl ester; 1,3-Thiazole-4-carboxylic acid, 5-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-(Trifluoromethyl)-1,3-thiazole-4-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and adherence to ISO standards ensure reliable supply for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.