Description

6-Bromo-5,7-Difluoroindoline-2,3-Dione is a high-purity, multi-functional halogenated isatin derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique bromo- and difluoro-substituted indoline-2,3-dione scaffold makes it a versatile building block for constructing complex heterocyclic systems with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides by incorporating its halogenated structure into bioactive molecules.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex functionality.
• Material Science: Serves as a monomer or precursor for creating specialized polymers, dyes, and organic electronic materials.
• Chemical Biology Probe Development: Utilized as a core structure for designing fluorescent probes or activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	6-Bromo-5,7-Difluoroindoline-2,3-Dione
CAS No.	1698027-85-8
Molecular Formula	C8H2BrF2NO2
Molecular Weight	273.01 g/mol
Synonyms	6-Bromo-5,7-difluoro-1H-indole-2,3-dione; 5,7-Difluoro-6-bromoisatin; 6-Bromo-5,7-difluoroisatin; 1H-Indole-2,3-dione, 6-bromo-5,7-difluoro-; 6-Br-5,7-F2-isatin
EINECS	Contact for details

Quality Control

Our 6-Bromo-5,7-Difluoroindoline-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep away from strong acids/bases and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.