Description

R-H8-(11Br)-4-Hydroxy-2,6-Bis(2,4,6-Tricyclohexylphenyl)-4-Oxide-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin is a sophisticated, chiral organophosphorus compound, specifically a phosphine oxide derivative, designed for high-performance applications. This compound matters as a highly effective chiral ligand or catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors where precise stereochemical control is critical.

Application

• Asymmetric Catalysis: Serving as a key chiral ligand for transition metal-catalyzed reactions such as hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate Synthesis: Enabling the stereoselective construction of complex active pharmaceutical ingredients (APIs) for novel therapeutics.
• Agrochemical Production: Facilitating the synthesis of enantiomerically pure herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Advanced Material Research: Acting as a building block or dopant in the development of chiral polymers, liquid crystals, or organic electronic materials.
• Methodology Development: Used in academic and industrial research laboratories to develop new catalytic systems and synthetic methodologies.
• Scale-up Process Chemistry: Implementation in pilot plants and commercial manufacturing for the production of high-value chiral compounds.

Basic Information

Product Name	R-H8-(11Br)-4-Hydroxy-2,6-Bis(2,4,6-Tricyclohexylphenyl)-4-Oxide-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin
CAS No.	1676072-26-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-H8-BINAP(O) Bromo Derivative; (R)-2,2'-Bis(di(2,4,6-tricyclohexylphenyl)phosphino)-1,1'-binaphthyl 4-Oxide Bromo Derivative; Chiral Dinaphthodioxaphosphepin Ligand; Asymmetric Phosphine Oxide Catalyst; CAS 1676072-26-6; BINAP(O)-Type Chiral Auxiliary; Brominated H8-BINAP Oxide Analog
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine oxide compounds is produced and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, Chiral HPLC, NMR, and MS to guarantee identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a desiccator or under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.