Description

2-(2-Methoxyphenyl)-1-(2,4,5,6,7-Pentadeuterio-1-Pentylindol-3-Yl)Ethanone is a deuterated synthetic cannabinoid receptor agonist, a high-value research chemical designed for advanced pharmacological and metabolic studies. Its core value lies in the strategic incorporation of deuterium atoms, which significantly enhances metabolic stability and alters pharmacokinetic profiles for more precise in-vitro and in-vivo investigations. This compound is essential for researchers and developers in pharmaceutical R&D, forensic science, and analytical chemistry who require well-characterized reference standards for method development and biological pathway analysis.

Application

• Pharmaceutical Research & Development: Used as a deuterium-labeled internal standard in LC-MS/MS and GC-MS for the quantitative analysis of synthetic cannabinoids and their metabolites in biological matrices.
• Metabolic Stability Studies: The pentadeuterio-labeled structure is critical for investigating the metabolic pathways, half-life, and bioavailability of related indole-based compounds.
• Forensic Toxicology: Serves as a certified reference material (CRM) for the accurate identification and quantification of novel psychoactive substances (NPS) in forensic casework and regulatory compliance testing.
• Biochemical Assay Development: Acts as a high-purity ligand for studying cannabinoid receptor (CB1/CB2) binding affinity, selectivity, and functional activity in receptor-based assays.
• Drug Discovery Programs: Provides a key chemical scaffold for structure-activity relationship (SAR) studies aimed at developing new therapeutic agents with modified pharmacokinetic properties.
• Academic Research: Employed in universities and research institutes for fundamental studies on the pharmacology and toxicology of synthetic cannabinoids.

Basic Information

Item	Detail
Product Name	2-(2-Methoxyphenyl)-1-(2,4,5,6,7-Pentadeuterio-1-Pentylindol-3-Yl)Ethanone
CAS No.	1651833-53-2
Molecular Formula	C23H21D5NO2
Molecular Weight	Contact for details
Synonyms	JWH-250-d5; 1-Pentyl-3-(2-methoxybenzoyl)indole-d5; 1-Pentyl-2,4,5,6,7-pentadeuterio-3-(2-methoxyphenylacetyl)indole; JWH 250 Deuterated Standard; JWH-250 Pentadeuterated; 2-(2-Methoxyphenyl)-1-(1-pentyl-2,4,5,6,7-pentadeuterio-1H-indol-3-yl)ethanone; JWH250-d5
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced under strict quality management systems. We guarantee high chemical and isotopic purity, verified through advanced analytical techniques including NMR (1H, 13C), mass spectrometry, and HPLC. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment (D-atom %), and confirming the absence of non-deuterated impurities. Our quality commitment ensures reliability for your most sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.