Description

6-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Protease Inhibitor Development: The bromo-spiroindole structure is valuable for creating potential inhibitors for specific enzyme targets.
• Ligand Synthesis for Receptor Studies: Employed in the development of selective ligands for pharmacological characterization of receptors.
• Chemical Biology Probes: Useful for creating tool compounds to study biological processes and identify new therapeutic targets.

Basic Information

Product Name	6-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride
CAS No.	1650548-73-4
Molecular Formula	C13H14BrN2O · HCl
Molecular Weight	346.63 g/mol (Free base: 310.17 g/mol)
Synonyms	6-Bromospiro[indole-3,4'-piperidin]-2(1H)-one hydrochloride; 6-Bromo-1,2-dihydrospiro[indole-3,4'-piperidine]-2-one HCl; 6-Bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine] hydrochloride; 1650548-73-4; Spiro[indole-3,4'-piperidine]-2-one, 6-bromo-1,2-dihydro-, hydrochloride; 6-Bromo-1'H-spiro[piperidine-4,3'-pyrrolo[2,3-c]pyridin]-2'(3'H)-one hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Bromo-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-2-One Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.