Description

1-Hydroxy(Ethyl-D4)-2'-Deoxyadenosine is a deuterated isotopologue of a modified nucleoside, featuring a deuterium-labeled ethyl group at the hydroxy position. This compound is of significant value as a stable isotope-labeled internal standard in quantitative bioanalytical methods, particularly liquid chromatography-mass spectrometry (LC-MS). It is primarily needed by pharmaceutical research organizations, contract research laboratories (CROs), and diagnostic developers for precise pharmacokinetic studies, metabolite quantification, and ensuring regulatory compliance in drug development.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a critical reference compound for the accurate quantification of nucleoside analogs and their metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) for novel therapeutic agents.
• Metabolite Identification and Profiling: Assists in the structural elucidation and concentration determination of drug metabolites in preclinical and clinical research.
• Diagnostic Assay Development: Serves as a calibrant or control in the development of high-sensitivity clinical diagnostic tests for specific biomarkers.
• Biochemical Research: Employed in enzymatic and metabolic pathway studies where tracking with a non-radioactive, stable isotope label is required.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in analytical methods to monitor the purity and consistency of active pharmaceutical ingredients (APIs) related to nucleoside chemistry.

Basic Information

Item	Detail
Product Name	1-Hydroxy(Ethyl-D4)-2'-Deoxyadenosine
CAS No.	1644566-71-1
Molecular Formula	C₁₂H₁₃D₄N₅O₄
Molecular Weight	Contact for details
Synonyms	2'-Deoxy-1-(2,2,2,2-tetradeuteroethoxy)adenine; 1-(2,2,2,2-Tetradeuteroethoxy)-2'-deoxyadenosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-(2,2,2,2-tetradeuteroethoxy)purin-6-amine; Deuterated 1-Hydroxyethyl-2'-deoxyadenosine; d4-1-HE-dA; Stable Isotope Labeled Nucleoside
EINECS	Contact for details

Quality Control

Every batch of 1-Hydroxy(Ethyl-D4)-2'-Deoxyadenosine is produced and analyzed under strict quality management protocols. We ensure high chemical and isotopic purity through advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere or desiccated upon opening for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.